Impulse control disorders in Parkinson's disease: decreased striatal dopamine transporter levels
Identifieur interne : 000D54 ( Main/Exploration ); précédent : 000D53; suivant : 000D55Impulse control disorders in Parkinson's disease: decreased striatal dopamine transporter levels
Auteurs : Valerie Voon [Royaume-Uni] ; Alexandra Rizos [Royaume-Uni] ; Riddhika Chakravartty [Royaume-Uni] ; Nicola Mulholland [Royaume-Uni] ; Stephanie Robinson [Royaume-Uni] ; Nicholas A. Howell [Royaume-Uni, Canada] ; Neil Harrison [Canada] ; Gill Vivian [Royaume-Uni] ; K. Ray Chaudhuri [Royaume-Uni]Source :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 2013.
Abstract
Impulse control disorders are commonly associated with dopaminergic therapy in Parkinson's disease (PD). PD patients with impulse control disorders demonstrate enhanced dopamine release to conditioned cues and a gambling task on [11C]raclopride positron emission tomography (PET) imaging and enhanced ventral striatal activity to reward on functional MRI. We compared PD patients with impulse control disorders and age-matched and gender-matched controls without impulse control disorders using [123I]FP-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT), to assess striatal dopamine transporter (DAT) density.
The [123I]FP-CIT binding data in the striatum were compared between 15 PD patients with and 15 without impulse control disorders using independent t tests.
Those with impulse control disorders showed significantly lower DAT binding in the right striatum with a trend in the left (right: F(1,24)=5.93, p=0.02; left: F(1,24)=3.75, p=0.07) compared to controls.
Our findings suggest that greater dopaminergic striatal activity in PD patients with impulse control disorders may be partly related to decreased uptake and clearance of dopamine from the synaptic cleft. Whether these findings are related to state or trait effects is not known. These findings dovetail with reports of lower DAT levels secondary to the effects of methamphetamine and alcohol. Although any regulation of DAT by antiparkinsonian medication appears to be modest, PD patients with impulse control disorders may be differentially sensitive to regulatory mechanisms of DAT expression by dopaminergic medications.
Url:
DOI: 10.1136/jnnp-2013-305395
PubMed: 23899625
PubMed Central: 4031642
Affiliations:
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Ray Chaudhuri</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>National Parkinson Foundation Centre of Excellence, Kings College Hospital, and Kings College</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23899625</idno><idno type="pmc">4031642</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031642</idno><idno type="RBID">PMC:4031642</idno><idno type="doi">10.1136/jnnp-2013-305395</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000A23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A23</idno><idno type="wicri:Area/Pmc/Curation">000A23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A23</idno><idno 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Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Behavioural and Clinical Neuroscience Institute, University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Cambridgeshire and Peterborough NHS Foundation Trust</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rizos, Alexandra" sort="Rizos, Alexandra" uniqKey="Rizos A" first="Alexandra" last="Rizos">Alexandra Rizos</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>National Parkinson Foundation Centre of Excellence, Kings College Hospital, and Kings College</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chakravartty, Riddhika" sort="Chakravartty, Riddhika" uniqKey="Chakravartty R" first="Riddhika" last="Chakravartty">Riddhika Chakravartty</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>National Parkinson Foundation Centre of Excellence, Kings College Hospital, and Kings College</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Department of Nuclear Imaging</addr-line>,<institution>Kings College Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mulholland, Nicola" sort="Mulholland, Nicola" uniqKey="Mulholland N" first="Nicola" last="Mulholland">Nicola Mulholland</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>National Parkinson Foundation Centre of Excellence, Kings College Hospital, and Kings College</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Department of Nuclear Imaging</addr-line>,<institution>Kings College Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Robinson, Stephanie" sort="Robinson, Stephanie" uniqKey="Robinson S" first="Stephanie" last="Robinson">Stephanie Robinson</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>National Parkinson Foundation Centre of Excellence, Kings College Hospital, and Kings College</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Howell, Nicholas A" sort="Howell, Nicholas A" uniqKey="Howell N" first="Nicholas A" last="Howell">Nicholas A. Howell</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Psychiatry</addr-line>,<institution>University of Cambridge</institution>,<addr-line>Cambridge</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af6"><institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Harrison, Neil" sort="Harrison, Neil" uniqKey="Harrison N" first="Neil" last="Harrison">Neil Harrison</name><affiliation wicri:level="1"><nlm:aff id="af6"><institution>University of Toronto</institution>,<addr-line>Toronto</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vivian, Gill" sort="Vivian, Gill" uniqKey="Vivian G" first="Gill" last="Vivian">Gill Vivian</name><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Department of Nuclear Imaging</addr-line>,<institution>Kings College Hospital</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ray Chaudhuri, K" sort="Ray Chaudhuri, K" uniqKey="Ray Chaudhuri K" first="K" last="Ray Chaudhuri">K. Ray Chaudhuri</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>National Parkinson Foundation Centre of Excellence, Kings College Hospital, and Kings College</institution>,<addr-line>London</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>Impulse control disorders are commonly associated with dopaminergic therapy in Parkinson's disease (PD). PD patients with impulse control disorders demonstrate enhanced dopamine release to conditioned cues and a gambling task on [<sup>11</sup>C]raclopride positron emission tomography (PET) imaging and enhanced ventral striatal activity to reward on functional MRI. We compared PD patients with impulse control disorders and age-matched and gender-matched controls without impulse control disorders using [<sup>123</sup>I]FP-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT), to assess striatal dopamine transporter (DAT) density.</p></sec><sec><title>Methods</title><p>The [<sup>123</sup>I]FP-CIT binding data in the striatum were compared between 15 PD patients with and 15 without impulse control disorders using independent t tests.</p></sec><sec><title>Results</title><p>Those with impulse control disorders showed significantly lower DAT binding in the right striatum with a trend in the left (right: F(1,24)=5.93, p=0.02; left: F(1,24)=3.75, p=0.07) compared to controls.</p></sec><sec><title>Conclusions</title><p>Our findings suggest that greater dopaminergic striatal activity in PD patients with impulse control disorders may be partly related to decreased uptake and clearance of dopamine from the synaptic cleft. Whether these findings are related to state or trait effects is not known. These findings dovetail with reports of lower DAT levels secondary to the effects of methamphetamine and alcohol. Although any regulation of DAT by antiparkinsonian medication appears to be modest, PD patients with impulse control disorders may be differentially sensitive to regulatory mechanisms of DAT expression by dopaminergic medications.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weintraub, D" uniqKey="Weintraub D">D Weintraub</name></author><author><name sortKey="Koester, J" uniqKey="Koester J">J Koester</name></author><author><name sortKey="Potenza, Mn" uniqKey="Potenza M">MN Potenza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steeves, Td" uniqKey="Steeves T">TD Steeves</name></author><author><name sortKey="Miyasaki, J" uniqKey="Miyasaki J">J Miyasaki</name></author><author><name sortKey="Zurowski, M" uniqKey="Zurowski M">M Zurowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Sullivan, Ss" uniqKey="O Sullivan S">SS 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uniqKey="Schmitt K">KC Schmitt</name></author><author><name sortKey="Reith, Me" uniqKey="Reith M">ME Reith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabinak, Ca" uniqKey="Rabinak C">CA Rabinak</name></author><author><name sortKey="Nirenberg, Mj" uniqKey="Nirenberg M">MJ Nirenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voon, V" uniqKey="Voon V">V Voon</name></author><author><name sortKey="Fernagut, Po" uniqKey="Fernagut P">PO Fernagut</name></author><author><name sortKey="Wickens, J" uniqKey="Wickens J">J Wickens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chernoloz, O" uniqKey="Chernoloz O">O Chernoloz</name></author><author><name sortKey="El Mansari, M" uniqKey="El Mansari M">M El Mansari</name></author><author><name sortKey="Blier, P" uniqKey="Blier P">P Blier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harden, Dg" uniqKey="Harden D">DG Harden</name></author><author><name sortKey="Grace, Aa" uniqKey="Grace A">AA Grace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grace, Aa" uniqKey="Grace A">AA Grace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ray, Nj" uniqKey="Ray N">NJ Ray</name></author><author><name sortKey="Miyasaki, Jm" uniqKey="Miyasaki J">JM Miyasaki</name></author><author><name sortKey="Zurowski, M" uniqKey="Zurowski M">M Zurowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nirenberg, Mj" uniqKey="Nirenberg M">MJ Nirenberg</name></author><author><name sortKey="Vaughan, Ra" uniqKey="Vaughan R">RA Vaughan</name></author><author><name sortKey="Uhl, Gr" uniqKey="Uhl G">GR Uhl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, Js" uniqKey="Schneider J">JS Schneider</name></author><author><name sortKey="Rothblat, Ds" uniqKey="Rothblat D">DS Rothblat</name></author><author><name sortKey="Distefano, L" uniqKey="Distefano L">L DiStefano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sulzer, D" uniqKey="Sulzer D">D Sulzer</name></author><author><name sortKey="Chen, Tk" uniqKey="Chen T">TK Chen</name></author><author><name sortKey="Lau, Yy" uniqKey="Lau Y">YY Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sulzer, D" uniqKey="Sulzer D">D Sulzer</name></author><author><name sortKey="Sonders, Ms" uniqKey="Sonders M">MS Sonders</name></author><author><name sortKey="Poulsen, Nw" uniqKey="Poulsen N">NW Poulsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laruelle, M" uniqKey="Laruelle M">M Laruelle</name></author><author><name sortKey="Baldwin, Rm" uniqKey="Baldwin R">RM Baldwin</name></author><author><name sortKey="Malison, Rt" uniqKey="Malison R">RT Malison</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name></noRegion><name sortKey="Chakravartty, Riddhika" sort="Chakravartty, Riddhika" uniqKey="Chakravartty R" first="Riddhika" last="Chakravartty">Riddhika Chakravartty</name><name sortKey="Chakravartty, Riddhika" sort="Chakravartty, Riddhika" uniqKey="Chakravartty R" first="Riddhika" last="Chakravartty">Riddhika Chakravartty</name><name sortKey="Howell, Nicholas A" sort="Howell, Nicholas A" uniqKey="Howell N" first="Nicholas A" last="Howell">Nicholas A. Howell</name><name sortKey="Mulholland, Nicola" sort="Mulholland, Nicola" uniqKey="Mulholland N" first="Nicola" last="Mulholland">Nicola Mulholland</name><name sortKey="Mulholland, Nicola" sort="Mulholland, Nicola" uniqKey="Mulholland N" first="Nicola" last="Mulholland">Nicola Mulholland</name><name sortKey="Ray Chaudhuri, K" sort="Ray Chaudhuri, K" uniqKey="Ray Chaudhuri K" first="K" last="Ray Chaudhuri">K. Ray Chaudhuri</name><name sortKey="Rizos, Alexandra" sort="Rizos, Alexandra" uniqKey="Rizos A" first="Alexandra" last="Rizos">Alexandra Rizos</name><name sortKey="Robinson, Stephanie" sort="Robinson, Stephanie" uniqKey="Robinson S" first="Stephanie" last="Robinson">Stephanie Robinson</name><name sortKey="Vivian, Gill" sort="Vivian, Gill" uniqKey="Vivian G" first="Gill" last="Vivian">Gill Vivian</name><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name></country><country name="Canada"><noRegion><name sortKey="Howell, Nicholas A" sort="Howell, Nicholas A" uniqKey="Howell N" first="Nicholas A" last="Howell">Nicholas A. Howell</name></noRegion><name sortKey="Harrison, Neil" sort="Harrison, Neil" uniqKey="Harrison N" first="Neil" last="Harrison">Neil Harrison</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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